Special and differential treatment is a preferential privilege granted by the WTO to developing member countries.It is a basic principle of the WTO in dealing with problems in the economic development of developing member countries.The Regional Comprehensive Economic Partnership Agreement （RCEP） has followed the special and differential treatment clauses in its dispute settlement mechanism， and the relevant contents are highly legitimate.However，the special and differential treatment clauses in the RCEP dispute settlement mechanism have some problems，such as unclear objects，vague relevant procedures and low enforceability of the clauses，which pose a huge challenge to the application of clauses.In order to better implement the special and differential treatment clauses in the RCEP dispute settlement mechanism，it is necessary to set the realization of the interests of the least developed countries as the starting point，add provisions with clear concepts，enhance the accuracy and enforceability of the clauses，so as to a long-term path to apply special and differential treatment.