The supply-side structural reform of agriculture and the rural revitalization strategy are two important main points about general trend of the rural development. There is an intrinsic connection between them. On the one hand, the supply-side structural reform of agriculture supplies power and channel for the rural revitalizing. On the other hand, the rural revitalization strategy can create favorable conditions for the supply-side structural reform of agriculture. Northern Anhui region, as the main grain-producing area and traditional agricultural areas, the rural revitalization is constrained by factors such as the poor quality of agricultural base, high stock pressure of grain output, distortion of agricultural product structure caused by mismatches of factors, Anhui Province's main functional area planning and negative environmental effects. The breakthrough to promote the implementation of rural revitalization strategy in northern Anhui is to speed up the pace of the supply-side structural reform of agriculture. So this article suggests to make strategic adjustments to the agricultural structure, gradually to improve the rural governance system, to promote the integrated development of rural industries, and to deepen the reform of factor marketization.