the spirit of artisan has been a morality pursued by Chinese craftsmen, and it is also the demand in building top projects in the era of“Internet +”. This paper analyzes the connotation of“the spirit of artisan”and illustrates its connection with the cultivation of applied talents, taking Tianfu Vocational and Technical School as an example. At last, methods have been put forwarded in the cultivation of applied talents with“the spirit of artisan”.