This paper first introduces the historical origin of Guangzhou port to foreign trade development, then emphatically discusses on its manipulation andcontrol by U.S. imperialism in collusion with Chiang Kai-shek during the War of Liberation,thus providing a comprehensive analysis of the tough condition of its external trade development as well as the thoughtful pondering it has laid to us later generations, and lastly puts forward some suggestions for the future development of foreign trade of Guangzhou port and places great expectations on its further development.