Since the introduction of Vimalakirti Nirdesa Sutra to China, many people have attempted to translate and annotate it. Poets such as Wang Wei, Li Shangyin, Bai Juyi, Wang Anshi, and Shu Shi have read it and left some poems on it. Therefore, we can see the profoundness of its influence upon Chinese culture. Among all its influences, the influence of its expressing wisdom on Chinese traditional culture is the most important. Its relationship with Chinese philosophical thoughts is very complicated. This article is intended to study its infuence by explaining its relationship to the metaphysics of Wei and Jin dynasty, the style of Zen Buddhism, and the zen poems of South and North Song.