Universities enjoy abundant talents and advantageous scientific researches, and their active involvement in the targeted poverty alleviation tasks is required by their "social service" function as well as by their obligatory historical mission. As a university located in the poverty-stricken region of Liangshan prefecture, Xichang University has more empirical understanding of the current situation and more direct involvement in poverty-stricken regions. Based on Xichang University’s poverty alleviation practices in Liangshan Ethnic Yi Autonomous Prefecture, one of the poverty-stricken“Three Regions and Three Prefectures”supported by the central government as well as a major battlefield of poverty alleviation for Sichuan province, this paper summarizes its experiences and determines the problems in its practices, and proposes an optimized path for solving the difficulties in practices, in order to improve the performance of poverty alleviation work, and to explore new ways for universities’poverty alleviation work that can be replicated and extended.