According to international practice，the free human organ donation systems have been implemented in China, but the enthusiasm of organ donation is low. One of the reasons is that the rights of organ donors can not get effective protection. On the basis of free human organ donation system, this article tries to explore the incentive mechanism of human organ donation from three dimensions, which are economic compensation, moral rewards and social security. Accordingly, the rights of organ donors should be guaranteed, and the motivation of organ donation should be improved, so that the human organ transplant technology should be used widely and beneficial for the human beings.