In this paper we explore the effective strategy for senior middle school English teaching and learning in ethnic regions. With regard to the present situation and the problems of senior school English teaching and learning in the ethnic Yi region, and based on cognitive language acquisition theories, successful cases of English learning practices and text books, we propose the strategy of choice reading as the breakthrough point for senior school English teaching and learning in ethnic regions. We also give a brief introduction to the achievements in our practices and extensions with this strategy.