At present, the number of girls in Higher Education in China has exceeded the number of boys. However, it is often seen that female college students＆#39; rights and interests is damaged due to their special physiological structure, psychological immature, the lack of social experience and other reasons. To effectively protect their legitimate rights and interests, they must enhance the awareness of safeguarding rights and interests, to be self-reliance, self-esteem, self-discipline, self-protection, self-care, and sensibly safeguard rights and interests.