Yi Cultural History of Chinese medicine is an important source of the legend on the myth of the history of medicine. In this paper, from the perspective of pharmaceutical culture （myth） the author discusses the origin of the Yi medicine： doctors from instinct, doctors from labor, from St. medicine, from medical thinking, such as witchcraft. Yi medicine and Chinese medicine, like other medicines, is a treasure house of traditional Chinese medicines, It is worth in-depth studing and excavation.