Moral education is the education that can mold one's spirit. It's very important to mold undergraduates'spirit in the 21th century. If colleges and universities ignore undergraduates'otherness and era or subjectivity and practicing,undergraduates'spirit will suffer drug resistance during moral education process. In this paper,the author will introduce drug resistance and its'reason. And at the same time,we try to find tactic that can cure drug resistance through researching undergraduates'demands.