College Party Branches is the fortress to play the role of Party. The effectiveness of Party branches construction directly affects the implementation of the Party’s principles, lined and policies in colleges. Based on “six in one”mixed development method to promote the Standardization and Normalization Construction of College Party Branches. The paper give the specific implementation methods and measures from the aspects of ideological guidance, style guidance, quality guidance, goal guidance, method guidance and typical guidance . Based on National Model branch of Party Construction of Ministry of Education, the Practice and verification show that the effect is good. The research results provide the ideas and guidance for Construction of College Party Branches.