The innovation of science and technology, the refinement of social division of labor, the self-characteristics of the audience and the acceleration of the pace of life have accelerated the emergence of the context of fragmentation.Interpretation of the three new situations of the May 4th spirit with patriotism, progress, democracy, and science as the main content in the context of fragmentation, one-sidedness of the spiritual essence, oblivion of scientific connotation, and outdated value of the times, so that the spirit of the May 4th is correct inheritance and development.Studies have shown that to break the current three situations, we must start with three paths: The first is to promote the essence of the May 4th spirit to return to the original and never fade; the second is to promote the connotation of the May 4th spirit science to be internalized in the heart and externalized in the practice; the third is to promote the time value of May 4th spirit leading development and realizing our dream.In the process of interpretation, reflecting on the historical value and practical significance of the May 4th spirit will play an important role in building a harmonious socialist society and realizing the great rejuvenation of the Chinese nation.